Edorium Journal of

Clinical Research

 
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Original Article
 
Influence of clinical history and demographic factors on infertility patients' willingness to participate in clinical research
Megan L. McCoin1, Valerie A. Flores1, Carol A. Wheeler2, Vrishali Lopes3, Kristen A. Matteson4
1MD, Resident, Department of Obstetrics & Gynecology, Women & Infants Hospital of Rhode Island, Providence, RI, USA.
2MD, Associate Professor, Department of Obstetrics & Gynecology, Women & Infants Hospital of Rhode Island, Providence, RI, USA.
3MS, Database Administrator, Division of Research, Women & Infants Hospital of Rhode Island, Providence, RI, USA.
4MD, MPH, Interim Director, Division of Research, Associate Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Women & Infants Hospital 101 Dudley Street, Providence, Rhode Island, USA.

Article ID: 100001C08MM2015
doi:10.5348/C08-2015-1-OA-1

Address correspondence to:
Kristen A. Matteson
MD, MPH, Interim Director, Division of Research, Associate Professor of Obstetrics and Gynecology
Department of Obstetrics and Gynecology, Women & Infants Hospital
101 Dudley Street, Providence, Rhode Island 02905
USA
Phone: +1 401-274-1100 x 48562, +1 401-276-7871

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How to cite this article
McCoin ML, Flores VA, Wheeler CA, Lopes V, Matteson KA. Influence of clinical history and demographic factors on infertility patients' willingness to participate in clinical research. Edorium J Clin Res 2015;1:1–7.


Abstract
Aims: To identify factors associated with patient willingness to participate in clinical research within a population of infertility patients.
Methods: We performed a cross sectional survey of women undergoing evaluation or treatment of infertility at The Center for Reproduction and Infertility at Women and Infants Hospital between August 2010 and April 2011. The survey questions included information on demographic factors, infertility history and treatments, knowledge about clinical research and willingness to participate in research.
Results: Questionnaires were distributed to 272 women and 213 (78%) participated. Thirty three percent of participants (n=72) indicated that they would be willing to participate in clinical research, 38% (n=81) were uncertain and 28% (n=60) indicated that they would not consider participation in clinical research. Compared to patients with less than six months of infertility treatments, patients with a history of more than six months of infertility treatment were at increased odds for reporting willingness to participate in research [OR 3.86 95% CI (1.3–11)]. Similarly, patients with previous participation in clinical research were more likely to report willingness to participate in clinical research [OR 8.29 95% CI (2.1 – 31.9)]. These associations were still present when controlled for other factors and potential confounders.
Conclusion: Factors associated with willingness to participate in clinical research included a history of more than six months of infertility treatment and previous participation in clinical research. Understanding factors associated with patient willingness to enter infertility research may help assist clinical trial recruitment strategies.

Keywords: Clinical research, Infertility patients, Participation

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Author Contributions:
Megan L. McCoin – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Valerie A. Flores – Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Carol A. Wheeler – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Vrishali Lopes – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Kristen A. Matteson – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Megan L. McCoin et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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